Mitochondria is a unique cellular organelle involved in multiple cellular processes and is
critical for maintaining cellular homeostasis. This semi-autonomous organelle contains its …

Friedreich ataxia, the most common recessive ataxia, is caused by the deficiency of the
mitochondrial protein frataxin (Fxn), an iron chaperone involved in the assembly of Fe–S …

We developed a system for tracing DNA adducts in targeted mutagenesis (TATAM) and
investigated the prevalence and types of consequent mutations. Targeted mutagenesis …

DNA damage and mutagenesis are suggested to contribute to aging through their ability to
mediate cellular dysfunction. The base excision repair (BER) pathway ameliorates a large …

Free radical attack on the C1′ position of DNA deoxyribose generates the oxidized abasic
(AP) site 2-deoxyribonolactone (dL). Upon encountering dL, AP lyase enzymes such as …

Cockayne syndrome (CS) is a premature aging condition characterized by sensitivity to UV
radiation. However, this phenotype does not explain the progressive neurodegeneration in …

Background The base excision repair pathway is responsible for repairing small DNA base
lesions caused by endogenous and exogenous damaging agents. Repair is initiated by …

Background & Aims: The human mutyh gene encodes a base excision repair protein that
prevents G: C to T: A transversions in DNA. Biallelic mutations in this gene are associated …

The histo-pathologic and molecular mechanisms leading to initiation and progression of
hepatocellular carcinoma (HCC) are still ill-defined; however, there is increasing evidence …

It is generally believed that the mammalian nucleotide excision repair pathway removes
DNA helix-distorting bulky DNA lesions, while small non-bulky lesions are repaired by base …