Apurinic/apyrimidinic (AP) endonucleases are versatile DNA repair enzymes that possess a
variety of nucleolytic activities, including endonuclease activity at AP sites, 3 …

A major product of oxidative DNA damage is 8-oxoguanine. In humans, 8-oxoguanine DNA
glycosylase (hOGG1) facilitates removal of these lesions, producing an abasic (AP) site in …

Clustered DNA lesions, possibly induced by ionizing radiation, constitute a trial for repair
processes. Indeed, recent studies suggest that repair of such lesions may be compromised …

During the COVID-19 pandemic, excess deaths including cancer have become a concern in
Japan, which has a rapidly aging population. Thus, this study aimed to evaluate how age …

Background Friedreich ataxia (FRDA), the most common form of recessive ataxia, is due to
reduced levels of frataxin, a highly conserved mitochondrial iron-chaperone involved in iron …

Genetic information must be duplicated with precision and accurately passed on to daughter
cells and later generations. In order to achieve this goal, DNA polymerases (Pols) have to …

A developing human fetus needs to balance rapid cellular expansion with maintaining
genomic stability. Here, we accurately quantified and characterized somatic mutation …

Abstract A uracil DNA glycosylase (UDG) from Mycobacterium smegmatis (Msm UdgX)
shares sequence similarity with family 4 UDGs and forms exceedingly stable complexes with …

Helicobacter pylori infection induces a plethora of DNA damages. Gastric epithelial cells, in
order to maintain genomic integrity, require an integrous DNA damage repair (DDR) …

Background DNA damage by endogenous or exogenous source of reactive oxygen species
(ROS) plays an important role in induction and progression of various cancers …