Background Cardiovascular disease (CVD) is the greatest contributor to global morbidity
and mortality. Poor social health plays a critical role in CVD incidence. Additionally, the …

Neurodegenerative diseases are increasing in prevalence and place a significant burden on
society. The causes are multifactorial and complex, and increasing evidence suggests a …

Loneliness, or the subjective feeling of social isolation, is an important social determinant of
health. Loneliness is associated with poor physical health, including higher rates of …

Abstract Background Apolipoprotein-E (APOE) ε4 and ε2 are the most prevalent risk-
increasing and risk-reducing genetic predictors of Alzheimer's disease, respectively …

This review addresses key findings on loneliness from the social, neurobiological and
clinical fields. From a translational perspective, results from studies in humans and animals …

Background Aging is associated with many personal, social, and environmental challenges
that increase the risk of loneliness. Loneliness is a painful emotional experience associated …

Objectives Life events can be stressful and have a detrimental impact on health, but
evidence is inconclusive regarding life events and dementia risk. The present study tests …

It is widely accepted that loneliness is associated with health problems, but less is known
about the predictors of loneliness. In this study, we constructed a model to predict individual …

Loneliness significantly contributes to cognitive impairment and dementia in older adults.
Loneliness is a distressing feeling resulting from a perceived lack of social connection (ie, a …

Importance Loneliness is associated with morbidity and mortality, including higher risk of
neurodegenerative diseases. To our knowledge, no study has examined whether the …