Update on cannabis and cannabinoids for cancer pain
To date, preclinical data has demonstrated evidence to suggest promising potential for
cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to …
cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to …
Sigma1 pharmacology in the context of cancer
FJ Kim, CM Maher - Sigma Proteins: Evolution of the Concept of Sigma …, 2017 - Springer
Sigma1 (also known as sigma-1 receptor, Sig1R, σ1 receptor) is a unique pharmacologically
regulated integral membrane chaperone or scaffolding protein. The majority of publications …
regulated integral membrane chaperone or scaffolding protein. The majority of publications …
A novel sulfate-bridged binuclear copper (II) complex: Structure, optical, ADMET and in vivo approach in a murine model of bone metastasis
The novel sulfate-bridged binuclear copper (II) complex namely [Cu2 (μ3-SO4) 2 (C4H6N2)
4](1) was obtained from the hydrothermal reaction of 2-methylimidazole (hereafter …
4](1) was obtained from the hydrothermal reaction of 2-methylimidazole (hereafter …
Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo …
This study investigated Allium subhirsutum L.(AS) anticancer and antioxidant effects and
inhibition of tumor angiogenesis in a murine model of skeletal metastases due to inoculation …
inhibition of tumor angiogenesis in a murine model of skeletal metastases due to inoculation …
[HTML][HTML] PRG-1 relieves pain and depressive-like behaviors in rats of bone cancer pain by regulation of dendritic spine in hippocampus
X Liu, Z Xie, S Li, J He, S Cao, Z Xiao - International journal of …, 2021 - ncbi.nlm.nih.gov
Rationale: Pain and depression, which tend to occur simultaneously and share some
common neural circuits and neurotransmitters, are highly prevalent complication in patients …
common neural circuits and neurotransmitters, are highly prevalent complication in patients …
Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo
M Rauschner, L Lange, T Hüsing, S Reime… - Journal of Experimental …, 2021 - Springer
Background The low extracellular pH (pH e) of tumors resulting from glycolytic metabolism is
a stress factor for the cells independent from concomitant hypoxia. The aim of the study was …
a stress factor for the cells independent from concomitant hypoxia. The aim of the study was …
Vascular endothelial growth factor a signaling promotes spinal central sensitization and pain-related behaviors in female rats with bone cancer
XM Hu, W Yang, LX Du, WQ Cui, WL Mi… - …, 2019 - pubs.asahq.org
Abstract Editor's Perspective What We Already Know about This Topic Pain resulting from
cancer metastatic to bone is a major clinical problem Vascular endothelial growth factor …
cancer metastatic to bone is a major clinical problem Vascular endothelial growth factor …
Spinal Nrf2 translocation may inhibit neuronal NF‐κB activation and alleviate allodynia in a rat model of bone cancer pain
J Fu, C Ni, HD Ni, LS Xu, QL He, H Pan… - Journal of …, 2021 - Wiley Online Library
Bone cancer pain (BCP) is a clinical pathology that urgently needs to be solved, but
research on the mechanism of BCP has so far achieved limited success. Nuclear factor …
research on the mechanism of BCP has so far achieved limited success. Nuclear factor …
The analgesic effects of triptolide in the bone cancer pain rats via inhibiting the upregulation of HDACs in spinal glial cells
XF Hu, XT He, KX Zhou, C Zhang, WJ Zhao… - Journal of …, 2017 - Springer
Background Bone cancer pain (BCP) severely compromises the quality of life, while current
treatments are still unsatisfactory. Here, we tested the antinociceptive effects of triptolide …
treatments are still unsatisfactory. Here, we tested the antinociceptive effects of triptolide …
[HTML][HTML] Role of transient receptor potential ankyrin 1 (TRPA1) on nociception caused by a murine model of breast carcinoma
AS de Almeida, FK Rigo, SDT De Prá, AM Milioli… - Pharmacological …, 2020 - Elsevier
Breast carcinoma causes severe pain, which decreases the quality of life of patients. Current
treatments produce adverse effects and have limited efficacy. Transient potential receptor …
treatments produce adverse effects and have limited efficacy. Transient potential receptor …