Optimization and In Vivo Profiling of a Refined Rat Model of Walker 256 Breast Cancer Cell-Induced Bone Pain Using Behavioral, Radiological, Histological …

P Shenoy, A Kuo, I Vetter, MT Smith - Frontiers in pharmacology, 2017 - frontiersin.org
In the majority of patients with advanced breast cancer, there is metastatic spread to bones
resulting in pain. Clinically available drug treatments for alleviation of breast cancer-induced …

ALKBH5 modulates bone cancer pain in a rat model by suppressing NR2B expression

K Song, Q Cao, Y Yang, Y Zuo… - … and Applied Biochemistry, 2024 - Wiley Online Library
Currently, the clinical treatment of bone cancer pain (BCP) is mainly related to its
pathogenesis. The aim of the present study was to elucidate the potential role of N6 …

Amitriptyline influences the mechanical withdrawal threshold in bone cancer pain rats by regulating glutamate transporter GLAST

S Ma, X Zheng, T Zheng, F Huang, J Jiang… - Molecular …, 2019 - journals.sagepub.com
Patients with cancer, especially breast, prostate, and lung cancer, commonly experience
bone metastases that are difficult to manage and are associated with bone cancer pain …

Novel and conventional preclinical models to investigate bone metastasis

TE Kähkönen, J Bernoulli, JM Halleen… - Current Molecular …, 2019 - Springer
Abstract Purpose of Review The purpose of this review is to emphasize the use of bone
metastasis models in preclinical research. As classical models have been thoroughly …

[HTML][HTML] Antinociceptive effects of macrophage-derived extracellular vesicles by carrying microRNA-216a

X Cai, X Xi, X Li, X Zhang, X Zhang… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Cancer-induced bone pain (CIBP) represents the pain induced by bone metastases from
malignancies. The role of extracellular vesicles (Evs) has been underscored in bone …

[HTML][HTML] Neurotropin alleviates rat osteocarcinoma pain via P2X3 receptor activation in the midbrain periaqueductal gray

X Liu, J He, Z Xiao - Iranian Journal of Basic Medical Sciences, 2021 - ncbi.nlm.nih.gov
Objective (s): Clinically effective analgesia treatment for patients afflicted with
osteocarcinoma lessens the intensity of pain. The midbrain periaqueductal gray (PAG) plays …

Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell‐induced bone pain

PA Shenoy, A Kuo, G Leparc… - Clinical and …, 2019 - Wiley Online Library
In patients with breast cancer, metastases of cancer cells to the axial skeleton may cause
excruciating pain, particularly in the advanced stages. The current drug treatments available …

Bone Cancer Pain, Mechanism and Treatment

SHJ Sliepen - Recent Advances in Bone Tumours and …, 2021 - books.google.com
The world health organization (WHO) has predicted a global amount of 19 million cancer
cases by 2025. Breast, prostate and lung cancer are common cancer types and show …

Physical Exercise and Skeletal Muscle Adaptation in Cancer Cachexia

M Miyazaki - Physical Therapy and Research in Patients with …, 2023 - Springer
Cancer cachexia is a muscle wasting syndrome observed in cancer and other chronic
wasting diseases and is a highly challenging disorder to manage due to the complexity of its …

Genetic Determination of Regressive Pattern of Walker 256 Carcinosarcoma in Rats with Hypothalamic Diabetes Insipidus

II Khegay - Bulletin of Experimental Biology and Medicine, 2022 - Springer
We studied the growth dynamics of Walker 256 carcinosarcoma in recombinant progeny of
dihybrid crosses of Brattleboro and WAG rats. A mutation in the vasopressin gene …