Members of the diverse superfamily of AAA+ proteins are molecular machines responsible
for a wide range of essential cellular processes. In this review we summarise structural and …

Cdc48 is an essential, highly prominent ATP driven machine in eukaryotic cells.
Physiological function of Cdc48 has been found in a multitude of cellular processes, for …

p97 is a “segregase” that plays a key role in numerous ubiquitin (Ub)-dependent pathways
such as ER-associated degradation. It has been hypothesized that p97 extracts proteins …

Many complex cellular events depend on multiprotein complexes known as molecular
machines to efficiently couple the energy derived from adenosine triphosphate hydrolysis to …

The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-
containing p rotein), is an important therapeutic target for cancer and neurodegenerative …

Adenosine triphosphatases (ATPases) associated with a variety of cellular activities (AAA+),
the hexameric ring-shaped motor complexes located in all ATP-driven proteolytic machines …

Abstract The AAA+ Cdc48 ATPase (alias p97 or VCP) is a key player in multiple ubiquitin-
dependent cell signaling, degradation, and quality control pathways. Central to these broad …

The biogenesis of ribosomes is a fundamental cellular process, which provides the
molecular machines that synthesize all cellular proteins. The assembly of eukaryotic …

p97 is a homohexameric, toroidal machine that harnesses the energy of ATP binding and
hydrolysis to effect structural reorganization of a diverse and primarily uncharacterized set of …

Cdc48/p97 is a ring-shaped, ATP-driven hexameric motor, essential for cellular viability. It
specifically unfolds and extracts ubiquitylated proteins from membranes or protein …