Figure and caption extraction from biomedical documents

P Li, X Jiang, H Shatkay - Bioinformatics, 2019 - academic.oup.com
Motivation Figures and captions convey essential information in biomedical documents. As
such, there is a growing interest in mining published biomedical figures and in utilizing their …

Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf

J Clark, JM Silvaggi, T Kiselak, K Zheng, EL Clore… - PloS one, 2012 - journals.plos.org
Multiple mechanisms likely contribute to neuronal death in Parkinson's disease (PD),
including mitochondrial dysfunction and oxidative stress. Peroxisome proliferator-activated …

[HTML][HTML] Stem cell potential in Parkinson's disease and molecular factors for the generation of dopamine neurons

HJ Kim - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2011 - Elsevier
Parkinson's disease (PD) involves the loss of dopamine (DA) neurons, making it the most
expected neurodegenerative disease to be treated by cell replacement therapy. Stem cells …

Applications of Boolean modeling to study the dynamics of a complex disease and therapeutics responses

AA Hemedan, R Schneider… - Frontiers in bioinformatics, 2023 - frontiersin.org
Computational modeling has emerged as a critical tool in investigating the complex
molecular processes involved in biological systems and diseases. In this study, we apply …

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

S Montagud‐Romero… - European Journal of …, 2018 - Wiley Online Library
Social interaction is known to be the main source of stress in human beings, which explains
the translational importance of this research in animals. Evidence reported over the last …

Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB …

S Montagud-Romero, C Nuñez, MC Blanco-Gandia… - …, 2017 - Springer
Rationale Repeated social defeat (RSD) increases the rewarding effects of cocaine in
adolescent and adult rodents. Objective The aim of the present study was to compare the …

Epigenetic mechanisms in the development and maintenance of dopaminergic neurons

HJ van Heesbeen, S Mesman, JV Veenvliet… - …, 2013 - journals.biologists.com
Mesodiencephalic dopaminergic (mdDA) neurons are located in the ventral
mesodiencephalon and are involved in psychiatric disorders and severely affected in …

Gestational restraint stress and the developing dopaminergic system: an overview

CJ Baier, MR Katunar, E Adrover, ME Pallarés… - Neurotoxicity …, 2012 - Springer
Prenatal stress exerts a strong impact on fetal brain development in rats impairing
adaptation to stressful conditions, subsequent vulnerability to anxiety, altered sexual …

Alterations of neocortical development and maturation in autism: insight from valproic acid exposure and animal models of autism

T Chomiak, B Hu - Neurotoxicology and teratology, 2013 - Elsevier
Autism spectrum disorder (ASD) is a behaviourally defined brain disorder affecting
approximately 1 in 88 children. Many pathological studies have shown that ASD is …

Retinoic acid-dependent and-independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons

FMJ Jacobs, JV Veenvliet, WH Almirza… - …, 2011 - journals.biologists.com
Development of meso-diencephalic dopamine (mdDA) neurons requires the combined
actions of the orphan nuclear receptor Nurr1 and the paired-like homeobox transcription …