Recently, it has been shown that both decreased nuclear receptor-related 1 (Nurr1)
expression and thrombin accumulation are involved in the degeneration of dopaminergic …

Cultured neural stem/precursor cells (NSCs) are regarded as a potential systematic cell
source to treat Parkinson's disease (PD). However, the therapeutic potential of these …

In the central nervous system, embryonic and adult neural stem/progenitor cells (NSCs)
generate the enormous variety and huge numbers of neuronal and glial cells that provide …

The degeneration of dopaminergic and other neurons in the aging brain is considered a
process starting well beyond the infantile and juvenile period. In contrast to other dopamine …

During the development of the central nervous system (CNS), neurons and glia are derived
from multipotent neural stem cells (NSCs) undergoing self-renewal. NSC commitment and …

Induced pluripotent stem cells (iPSCs) hold great promise for in vitro generation of disease-
relevant cell types, such as mesodiencephalic dopaminergic (mdDA) neurons involved in …

The dopamine transporter (DAT) is the key regulator of dopaminergic transmission and is a
target of several xenobiotics, including pesticides and pharmacological agents. Previously …

The mesodiencephalic floor plate (mdFP) is the source of diverse neuron types. Yet, how
this structure is compartmentalized has not been clearly elucidated. Here, we identify a …

Meso-diencephalic dopaminergic (mdDA) neurons are critical for motor control and
cognitive functioning and their loss or dysfunction is associated with disorders such as …

The use of cocaine during pregnancy can affect the mother and indirectly might alter the
development of the embryo/foetus. Accordingly, in the present work our aim was to study in …