Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives

M Asif - International journal of medicinal chemistry, 2014 - Wiley Online Library
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge
consideration owing to their expanded applications in the field of pharmaceutical chemistry …

β-d-N4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome

N Urakova, V Kuznetsova, DK Crossman… - Journal of …, 2018 - Am Soc Microbiol
Venezuelan equine encephalitis virus (VEEV) is a representative member of the New World
alphaviruses. It is transmitted by mosquito vectors and causes highly debilitating disease in …

[HTML][HTML] How to approach and treat viral infections in ICU patients

T Kelesidis, I Mastoris, A Metsini, S Tsiodras - BMC infectious diseases, 2014 - Springer
Patients with severe viral infections are often hospitalized in intensive care units (ICUs) and
recent studies underline the frequency of viral detection in ICU patients. Viral infections in …

Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of …

CE Schroeder, T Yao, J Sotsky, RA Smith… - Journal of Medicinal …, 2014 - ACS Publications
Venezuelan equine encephalitis virus (VEEV) is an emerging pathogenic alphavirus that
can cause significant disease in humans. Given the absence of therapeutic options …

[HTML][HTML] Discovery of a novel compound with anti-Venezuelan equine encephalitis virus activity that targets the nonstructural protein 2

DH Chung, CB Jonsson, NA Tower, YK Chu… - PLoS …, 2014 - journals.plos.org
Alphaviruses present serious health threats as emerging and re-emerging viruses.
Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, can cause …

[PDF][PDF] Synthesis, antiviral and cytotoxic investigation of 2-phenyl-3-substituted quinazolin-4 (3H)-ones.

SK Krishnan, S Ganguly, R Veerasamy… - European Review for …, 2011 - researchgate.net
Synthesis, antiviral and cytotoxic investigation of 2-phenyl-3-substituted quinazolin-4(3H)-ones
Page 1 Abstract. – Objectives: A series of 3- (benzylideneamino)-2-phenyl quinazoline-4(3H)ones …

Sulfonamides: antiviral strategy for neglected tropical disease virus

RN Dash, AK Moharana… - Current Organic …, 2020 - ingentaconnect.com
The viral infections are a threat to the health system around the globe. Although more than
60 antiviral drugs have been approved by the FDA, most of them are for the management of …

[HTML][HTML] N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview

G Ahmad, M Sohail, M Bilal, N Rasool, MU Qamar… - Molecules, 2024 - mdpi.com
Viruses are a real threat to every organism at any stage of life leading to extensive infections
and casualties. N-heterocycles can affect the viral life cycle at many points, including viral …

Identification of novel quinazolin-4 (3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases

MTH Khan, R Khan, Y Wuxiuer, M Arfan… - Bioorganic & medicinal …, 2010 - Elsevier
A combinatorial series of novel quinazolin-4 (3H)-ones were synthesised and their
structures were established based on spectroscopic data (IR, NMR, EI-MS, and FAB-MS) …

Transition Metal–free Single Step Approach for Arylated Pyrazolopyrimidinones and Quinazolinones Using Benzylamines/Benzylalcohols/Benzaldehydes

AD Hudwekar, GL Reddy, PK Verma, S Gupta… - …, 2017 - Wiley Online Library
A transition metal‐free, one step approach has been developed for the synthesis of
pyrazolopyrimidinones using in‐situ condensation of benzylamines, benzylalcohol and …