Glucocorticoids

IM Adcock, S Mumby - Encyclopedia of Molecular Pharmacology, 2022 - Springer
Definition γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the
central nervous system. Structures involved in releasing and binding GABA as a …

Modeling TH2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma

PS Foster, S Maltby, HF Rosenberg… - Immunological …, 2017 - Wiley Online Library
In this review, we highlight experiments conducted in our laboratories that have elucidated
functional roles for CD 4+ T‐helper type‐2 lymphocytes (TH 2 cells), their associated …

Comorbidities in the management of patients with lung cancer

C Leduc, D Antoni, A Charloux… - European Respiratory …, 2017 - Eur Respiratory Soc
Lung cancer represents a major public health issue worldwide. Unfortunately, more than half
of them are diagnosed at an advanced stage. Moreover, even if diagnosed early, diagnosis …

microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines

SA Leon-Icaza, M Zeng, AG Rosas-Taraco - ExRNA, 2019 - Springer
MicroRNAs (miRNAs) are single-stranded RNAs of 17–24 nt. These molecules regulate
gene expression at the post-transcriptional level and are differentially expressed in viral …

MicroRNAs in asthma and respiratory infections: identifying common pathways

S Taka, P Tzani-Tzanopoulou… - Allergy, asthma & …, 2020 - synapse.koreamed.org
MicroRNAs (miRs) are single-stranded RNAs of 18-25 nucleotides. These molecules
regulate gene expression at the post-transcriptional level; several of these are differentially …

Modulation of experimental acute lung injury by exosomal miR-7704 from mesenchymal stromal cells acts through M2 macrophage polarization

WT Lin, HH Wu, CW Lee, YF Chen, L Huang… - … Therapy-Nucleic Acids, 2024 - cell.com
Acute lung injury (ALI) is a life-threatening condition with limited treatment options. The
pathogenesis of ALI involves macrophage-mediated disruption and subsequent repair of the …

The role of microRNAs in acute respiratory distress syndrome and sepsis, from targets to therapies: a narrative review

LK Lee, L Medzikovic, M Eghbali… - Anesthesia & …, 2020 - journals.lww.com
Acute respiratory distress syndrome (ARDS) is a significant cause of morbidity and mortality
in the intensive care unit (ICU) and is characterized by lung epithelial and endothelial cell …

Update on current views and advances on RSV infection

IN Mammas, SB Drysdale, B Rath… - International …, 2020 - spandidos-publications.com
Respiratory syncytial virus (RSV) infection represents an excellent paradigm of precision
medicine in modern paediatrics and several clinical trials are currently performed in the …

Corticosteroid resistance in asthma: Cellular and molecular mechanisms

G Caramori, F Nucera, S Mumby, FL Bello… - Molecular aspects of …, 2022 - Elsevier
Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They
prevent the recruitment and activation of lung immune and inflammatory cells and …

Regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS‐CoV‐2 and other respiratory viruses: A comprehensive …

C Chakraborty, M Bhattacharya… - Reviews in Medical …, 2024 - Wiley Online Library
Abstract miRNAs are single‐stranded ncRNAs that act as regulators of different human body
processes. Several miRNAs have been noted to control the human immune and …