Advances in hydrogels for stem cell therapy: regulation mechanisms and tissue engineering applications

G Liu, Y Zhou, X Zhang, S Guo - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Stem cell therapy has shown unparalleled potential in tissue engineering, but it still faces
challenges in the regulation of the stem cell fate. Inspired by the native stem cell niche, a …

Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

L Wang, Y Shi, J Jiang, C Li, H Zhang, X Zhang… - Small, 2022 - Wiley Online Library
The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB),
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …

Fusion between glioma stem cells and mesenchymal stem cells promotes malignant progression in 3D-bioprinted models

X Dai, Y Shao, X Tian, X Cao, L Ye, P Gao… - … Applied Materials & …, 2022 - ACS Publications
The interaction between glioma stem cells (GSCs) and mesenchymal stem cells (MSCs) in
the glioma microenvironment is considered to be an important factor in promoting tumor …

High-throughput FRAP analysis of solute diffusion in hydrogels

NR Richbourg, NA Peppas - Macromolecules, 2021 - ACS Publications
Increasingly accurate mathematical models have been developed to relate solute and
hydrogel properties to solute diffusion coefficients in hydrogels, primarily by comparing …

A Silk Fibroin Methacryloyl-Modified Hydrogel Promoting Cell Adhesion for Customized 3D Cell-Laden Structures

S Li, C Huang, H Liu, X Han, Z Wang… - ACS Applied Polymer …, 2022 - ACS Publications
Cell adhesion is the physical basis of tissue formation. Developing a kind of bioink with
tunable mechanical properties and the promotion of cell adhesion is a major challenge for …

[HTML][HTML] Engineering in vitro human tissue models through bio-design and manufacturing

YS Zhang, A Khademhosseini - Bio-Design and Manufacturing, 2020 - Springer
In the era of burgeoning breakthroughs around medical and biomedical technologies,
personalizing our medicine still sounds like a dream yet to be realized. Take cancer as an …

Development of conductive hydrogels: from design mechanisms to frontier applications

Y Hong, Z Lin, Z Luo, T Jiang, J Shang… - Bio-Design and …, 2022 - Springer
Owing to their excellent mechanical flexibility, electrical conductivity, and biocompatibility,
conductive hydrogels (CHs) are widely used in the fields of energy and power, and …

Structurally decoupled stiffness and solute transport in multi-arm poly (ethylene glycol) hydrogels

NR Richbourg, NA Peppas - Biomaterials, 2023 - Elsevier
Synthetic hydrogels are widely used as artificial 3D environments for cell culture, facilitating
the controlled study of cell-environment interactions. However, most hydrogels are limited in …

[PDF][PDF] Vascularizing the brain in vitro

A Aazmi, H Zhou, W Lv, M Yu, X Xu, H Yang, YS Zhang… - Iscience, 2022 - cell.com
The brain is arguably the most fascinating and complex organ in the human body.
Recreating the brain in vitro is an ambition restricted by our limited understanding of its …

[HTML][HTML] Biocompatible copolymer formulations to treat glioblastoma multiforme

LCS Erthal, OL Gobbo, E Ruiz-Hernandez - Acta Biomaterialia, 2021 - Elsevier
The treatment for glioblastoma multiforme (GBM) has not changed for more than 20 years
while the prognosis for the patients is still poor and most of them survive less than 1 year …