Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy
KDR Roth, EV Wenzel, M Ruschig, S Steinke… - Frontiers in cellular …, 2021 - frontiersin.org
Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …
Advancing the prevention and treatment of HIV in children: priorities for research and development
M Penazzato, CL Townsend, NA Sam-Agudu… - The Lancet …, 2022 - thelancet.com
Safe and effective paediatric formulations of the most promising antiretroviral drugs are
crucial to advance the treatment and prevention of HIV in neonates, infants, children, and …
crucial to advance the treatment and prevention of HIV in neonates, infants, children, and …
Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis
DA Spencer, BS Goldberg, S Pandey… - Nature …, 2022 - nature.com
Increasingly, antibodies are being used to treat and prevent viral infections. In the context of
HIV, efficacy is primarily attributed to dose-dependent neutralization potency and to a lesser …
HIV, efficacy is primarily attributed to dose-dependent neutralization potency and to a lesser …
Broadly neutralizing monoclonal antibodies for HIV prevention
MD Miner, L Corey, D Montefiori - Journal of the International …, 2021 - Wiley Online Library
Introduction The last 12 years have seen remarkable progress in the isolation and
characterization of at least five different epitope classes of HIV‐specific broadly neutralizing …
characterization of at least five different epitope classes of HIV‐specific broadly neutralizing …
Safety and pharmacokinetics of monoclonal antibodies VRC07-523LS and PGT121 administered subcutaneously for human immunodeficiency virus prevention
S Mahomed, N Garrett, EV Capparelli… - The Journal of …, 2022 - academic.oup.com
Background Effective, long-acting prevention approaches are needed to reduce human
immunodeficiency virus (HIV) incidence. We evaluated the safety and pharmacokinetics of …
immunodeficiency virus (HIV) incidence. We evaluated the safety and pharmacokinetics of …
Uses and challenges of antiviral polyclonal and monoclonal antibody therapies
EB Struble, JMO Rawson, T Stantchev, D Scott… - Pharmaceutics, 2023 - mdpi.com
Viral diseases represent a major public health concerns and ever-present risks for
developing into future pandemics. Antiviral antibody therapeutics, either alone or in …
developing into future pandemics. Antiviral antibody therapeutics, either alone or in …
Vaccinal effect of HIV-1 antibody therapy: dream or reality?
M Naranjo-Gomez, M Pelegrin - Current Opinion in HIV and AIDS, 2023 - journals.lww.com
HIV-1 bNAbs can enhance adaptive host immune responses in PLWH. The challenge now
is to exploit these immunomodulatory properties to design optimized therapeutic …
is to exploit these immunomodulatory properties to design optimized therapeutic …
Challenges and opportunities of therapies targeting early life immunity for pediatric HIV cure
SJ Berendam, AN Nelson, B Yagnik… - Frontiers in …, 2022 - frontiersin.org
Early initiation of antiretroviral therapy (ART) significantly improves clinical outcomes and
reduces mortality of infants/children living with HIV. However, the ability of infected cells to …
reduces mortality of infants/children living with HIV. However, the ability of infected cells to …
Shear-reversible clusters of HIV-1 in solution: stabilized by antibodies, dispersed by mucin
AI Ogundiran, TL Chang, A Ivanov, N Kumari… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT HIV-1 has eluded vaccine therapy for the past 40 years. The virus mutates
rapidly and is protected by a shifting glycan shield of mannose sugars, which has hindered …
rapidly and is protected by a shifting glycan shield of mannose sugars, which has hindered …
HIV cure: an acceptability scientific agenda
HIV cure: an acceptability scientific agenda : Current Opinion in HIV and AIDS HIV cure: an
acceptability scientific agenda : Current Opinion in HIV and AIDS Log in or Register Subscribe to …
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