CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition
EI Buchbinder, A Desai - American journal of clinical oncology, 2016 - journals.lww.com
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1)
immune checkpoints are negative regulators of T-cell immune function. Inhibition of these …
immune checkpoints are negative regulators of T-cell immune function. Inhibition of these …
Nanotechnology-empowered strategies in treatment of skin cancer
J Chandra, N Hasan, N Nasir, S Wahab… - Environmental …, 2023 - Elsevier
In current scenario skin cancer is a serious condition that has a significant impact on world
health. Skin cancer is divided into two categories: melanoma skin cancer (MSC) and non …
health. Skin cancer is divided into two categories: melanoma skin cancer (MSC) and non …
Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006)
Background Interim analyses of the phase 3 KEYNOTE-006 study showed superior overall
and progression-free survival of pembrolizumab versus ipilimumab in patients with …
and progression-free survival of pembrolizumab versus ipilimumab in patients with …
Overall survival in patients with advanced melanoma who received nivolumab versus investigator's choice chemotherapy in CheckMate 037: a randomized, controlled …
Purpose Until recently, limited options existed for patients with advanced melanoma who
experienced disease progression while receiving treatment with ipilimumab. Here, we report …
experienced disease progression while receiving treatment with ipilimumab. Here, we report …
Inhibition of immune checkpoints and vascular endothelial growth factor as combination therapy for metastatic melanoma: an overview of rationale, preclinical …
PA Ott, FS Hodi, EI Buchbinder - Frontiers in oncology, 2015 - frontiersin.org
The role of angiogenesis as a mediator of immune regulation in the tumor microenvironment
has recently come into focus. Furthermore, emerging evidence indicates that …
has recently come into focus. Furthermore, emerging evidence indicates that …
Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade
E Buchbinder, FS Hodi - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
The relationship between cancer and the immune system is complex and provides unique
therapeutic opportunities. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a regulatory …
therapeutic opportunities. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a regulatory …
Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma
Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in
human melanoma, and promotes melanoma metastasis. The dietary flavonoid apigenin is a …
human melanoma, and promotes melanoma metastasis. The dietary flavonoid apigenin is a …
Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma
R Iannone, L Miele, P Maiolino, A Pinto, S Morello - Neoplasia, 2013 - Elsevier
The A 2b receptor (A 2b R) belongs to the adenosine receptor family. Emerging evidence
suggest that A 2b R is implicated in tumor progression in some murine tumor models, but the …
suggest that A 2b R is implicated in tumor progression in some murine tumor models, but the …
Natural killer cells and regulatory T cells cross talk in hepatocellular carcinoma: exploring therapeutic options for the next decade
AG Bozward, F Warricker, YH Oo… - Frontiers in …, 2021 - frontiersin.org
Despite major advances in immunotherapy, hepatocellular carcinoma (HCC) remains a
challenging target. Natural Killer (NK) cells are crucial components of the anti-HCC immune …
challenging target. Natural Killer (NK) cells are crucial components of the anti-HCC immune …
Bringing natural killer cells to the clinic: ex vivo manipulation
RW Childs, M Berg - Hematology 2013, the American Society …, 2013 - ashpublications.org
Recently, there has been a substantial gain in our understanding of the role that natural
killer (NK) cells play in mediating innate host immune responses against viruses and cancer …
killer (NK) cells play in mediating innate host immune responses against viruses and cancer …