Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the
transition from acute to chronic pain. In response to injury, resident immune cells are …

Migraine is a complicated neurological disorder affecting 6% of men and 18% of women
worldwide. Various mechanisms, including neuroinflammation, oxidative stress, altered …

Recent studies suggested contribution of homocysteine (HCY) to neurodegenerative
disorders and migraine. However, HCY effect in the nociceptive system is essentially …

Local peripheral injury activates satellite glial cells (SGCs) in sensory ganglia, which may
contribute to chronic pain. We hypothesized that systemic inflammation affects sensory …

The orofacial region is a major focus of chronic neuropathic pain conditions characterized by
primary hyperalgesia at the site of injury and secondary hyperalgesia outside the injured …

Objective/Background.—The goal of this study was to better understand the cellular
mechanisms involved in proton stimulation of calcitonin gene‐related peptide (CGRP) …

The neuropeptide calcitonin gene-related peptide (CGRP) is implicated in the underlying
pathology of migraine by promoting the development of a sensitized state of primary and …

Herpes simplex virus type-1 (HSV-1) infections are known to alter the host metabolism for
efficient propagation in vitro. However, in vivo metabolic perturbations upon prolonged HSV …

Orofacial pain conditions including temporomandibular disorder (TMD) and migraine are
characterized by peripheral and central sensitization of trigeminal nociceptive neurons. The …

The trigeminal ganglion is implicated in the underlying pathology of migraine and
temporomandibular joint disorders (TMD), which are orofacial pain conditions involving …