[HTML][HTML] Anti-obesity drug discovery: advances and challenges

TD Müller, M Blüher, MH Tschöp… - Nature Reviews Drug …, 2022 - nature.com
Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

Sarcopenia and cardiovascular diseases

AA Damluji, M Alfaraidhy, N AlHajri, NN Rohant… - Circulation, 2023 - Am Heart Assoc
Sarcopenia is the loss of muscle strength, mass, and function, which is often exacerbated by
chronic comorbidities including cardiovascular diseases, chronic kidney disease, and …

Functions of interoception: From energy regulation to experience of the self

KS Quigley, S Kanoski, WM Grill, LF Barrett… - Trends in …, 2021 - cell.com
We review recent work on the functions of interoceptive processing, by which the nervous
system anticipates, senses, and integrates signals originating from the body. We focus on …

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

FM Gribble, F Reimann - Nature Reviews Endocrinology, 2019 - nature.com
Gut hormones have many key roles in the control of metabolism, as they target diverse
tissues involved in the control of intestinal function, insulin secretion, nutrient assimilation …

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022 - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

[HTML][HTML] Anxiety, depression, and the microbiome: a role for gut peptides

G Lach, H Schellekens, TG Dinan, JF Cryan - Neurotherapeutics, 2018 - Elsevier
The complex bidirectional communication between the gut and the brain is finely
orchestrated by different systems, including the endocrine, immune, autonomic, and enteric …

The association of periodontal diseases with metabolic syndrome and obesity

S Jepsen, J Suvan, J Deschner - Periodontology 2000, 2020 - Wiley Online Library
Periodontitis is a multifactorial chronic inflammatory disease associated with dysbiotic
plaque biofilms and characterized by progressive destruction of the tooth‐supporting …

[HTML][HTML] Novel agents for the pharmacological treatment of alcohol use disorder

EM Burnette, SJ Nieto, EN Grodin, LR Meredith… - Drugs, 2022 - Springer
Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

[HTML][HTML] Toward a wiring diagram understanding of appetite control

ML Andermann, BB Lowell - Neuron, 2017 - cell.com
Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …

Ghrelin, CCK, GLP-1, and PYY (3–36): secretory controls and physiological roles in eating and glycemia in health, obesity, and after RYGB

RE Steinert, C Feinle-Bisset, L Asarian… - Physiological …, 2017 - journals.physiology.org
The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …