Cancer remains the second leading cause of mortality, with nearly 10 million deaths
worldwide in 2020. In many cases, radiotherapy is used for its anticancer effects. However …

Intestinal stem cells (ISCs) play an important role in maintaining intestinal homeostasis via
promoting a healthy gut barrier. Within the stem cell niche, gut microbiota linking the …

Colorectal cancer (CRC) is the second most common cause of cancer death in the United
States. Every 3 years, the American Cancer Society provides an update of CRC statistics …

Background The continuous proliferation of intestinal stem cells followed by their tightly
regulated differentiation to epithelial cells is essential for the maintenance of the gut …

Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of
health issues and inflammatory diseases in modern society. The balance between energy …

Diet can impact on gut health and disease by modulating intestinal stem cells (ISCs).
However, it is largely unknown if and how the ISC niche responds to diet and influences ISC …

The gastrointestinal tract is a functionally and anatomically segmented organ that is
colonized by microbial communities from birth. While the genetics of mouse gut …

Simple Summary The intestinal epithelium—a single-cell layer lining the luminal surface of
the small and large intestine—comprises an array of highly specialized cell types that …

Insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP2, also known as IMP2), a novel
class III N6-methyladenosine (m6A) reader, has recently gained attention due to its critical …

Non-communicable diseases (NCDs) have replaced communicable diseases as the leading
cause of premature death worldwide over the past century. Increasing numbers of studies …