The renin angiotensin system as a therapeutic target in traumatic brain injury

S Villapol, ZC Janatpour, KO Affram, AJ Symes - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

[HTML][HTML] Is it time for a paradigm shift in the treatment of schizophrenia? the use of inflammation-reducing and neuroprotective Drugs—A review

A Messina, C Concerto, A Rodolico, A Petralia… - Brain Sciences, 2023 - mdpi.com
Comprehending the pathogenesis of schizophrenia represents a challenge for global
mental health. To date, although it is evident that alterations in dopaminergic, serotonergic …

Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1: RAGE signaling and reversed by increased LAIR-1 expression

KR Carroll, M Mizrachi, S Simmons, B Toz… - Nature …, 2024 - nature.com
Cognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus
erythematosus, present in up to 80% of patients and leading to a diminished quality of life. In …

Identification of angiotensin‐converting enzyme inhibitory peptides from peanut meal (Arachis hypogaea Linn) fermented by Lactobacillus pentosus using MALDI …

W Li, Y Guan, L Shi, Y Chen, H Huang, H Zhen… - Food …, 2024 - Wiley Online Library
This study focused on the production of angiotensin‐converting enzyme inhibitory peptides
(ACEIPs) from peanut meal (Arachis hypogaea Linn) fermented by Lactobacillus pentosus …

[HTML][HTML] High-throughput single biomarker identification using droplet nanopore

LL Zhang, CB Zhong, TJ Huang, LM Zhang, F Yan… - Chemical …, 2024 - pubs.rsc.org
Biomarkers are present in various metabolism processes, demanding precise and
meticulous analysis at the single-molecule level for accurate clinical diagnosis. Given the …

Current understanding of the link between angiotensin-converting enzyme and pain perception

KD Bhilare, P Dobariya, F Hanak, PE Rothwell… - Drug Discovery …, 2024 - Elsevier
The renin–angiotensin system (RAS) is known to affect diverse physiological processes that
affect the functioning of many key organs. Angiotensin-converting enzyme (ACE) modulates …

The potential role of brain renin‐angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat?

Z Al‐Qahtani, HM Al‐kuraishy… - Journal of Cellular …, 2024 - Wiley Online Library
Parkinson disease (PD) is one of the most common neurodegenerative diseases of the
brain. Of note, brain renin‐angiotensin system (RAS) is intricate in the PD neuropathology …

[HTML][HTML] Angiotensin-converting enzyme inhibition prevents l-dopa-induced dyskinesia in a 6-ohda-induced mouse model of Parkinson's disease

HY Park, GS Lee, J Go, YK Ryu, CH Lee… - European Journal of …, 2024 - Elsevier
Parkinson's disease (PD) is characterised by severe movement defects and the
degeneration of dopaminergic neurones in the midbrain. The symptoms of PD can be …

Signaling pathways and genetics of brain Renin angiotensin system in psychiatric disorders: State of the art

R Barak, G Goshtasbi, R Fatehi… - … Biochemistry and Behavior, 2024 - Elsevier
Along the conventional pathways, Renin-angiotensin system (RAS) plays a key role in the
physiology of the CNS and pathogenesis of psychiatric diseases. RAS is a complex …

Total Synthesis and Bioactivity Profile of (+)-Ieodomycins A and B and their Stereoisomers

DB Sung, DB Choi, JH Seol, N Kang, EA Kim… - ACS …, 2024 - ACS Publications
Herein, we report the first-and second-generation syntheses of (+)-ieodomycins A and B and
their stereoisomers via the late-stage elaboration of their conjugated E-diene side chains …