Context Despite increasing awareness about the potential impact of financial conflicts of
interest on biomedical research, no comprehensive synthesis of the body of evidence …

Importance The current recommendation is for at least 12 months of dual antiplatelet therapy
after implantation of a drug-eluting stent. However, the optimal duration of dual antiplatelet …

Background The relative efficacy of streptokinase and tissue plasminogen activator and the
roles of intravenous as compared with subcutaneous heparin as adjunctive therapy in acute …

BACKGROUND Aortic counterpulsation has been observed to reduce the rate of reocclusion
of the infarct-related artery after patency has been restored during acute myocardial …

Background There is substantial concern that financial conflicts of interest on the part of
investigators conducting clinical trials may compromise the well-being of research subjects …

Thrombolytic therapy remains a mainstay for the treatment of patients with acute myocardial
infarction. This therapy has been the subject of intense investigation and multiple studies as …

Financial conflicts of interest in a research setting can adversely affect patient care, teaching,
and research. Discussions of these conflicts ordinarily focus on issues that arise when …

Patients with ST-segment elevation myocardial infarction (STEMI) admitted during
nonregular working hours (off-hours) have been reported to have greater mortality than …

Background Traditional time-to-event analysis assigns equal weight to the first event in the
composite end point. This is counterintuitive to many stakeholders. Methods We constructed …

Background Patients with prior coronary bypass surgery with acute ST-segment elevation
myocardial infarction (MI) pose an increasingly common clinical problem. We assessed the …