Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …

This review article provides an overview of the different species that α‐synuclein aggregates
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …

Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the
main pathological drivers in the disease, although it remains unclear how this protein elicits …

Adverse intra-and extracellular effects of toxic α-synuclein are believed to be central to the
pathogenesis in Parkinson's disease and other disorders with Lewy body pathology in the …

Iron is essential for life. Many enzymes require iron for appropriate function. However,
dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

Many lines of evidence suggest that the Parkinson's disease (PD)-related protein α-
synuclein (α-SYN) can propagate from cell to cell in a prion-like manner. However, the …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

α-Synuclein (αSyn) aggregation and mitochondrial dysfunction both contribute to the
pathogenesis of Parkinson disease (PD). Although recent studies have suggested that …

Oligomeric forms of alpha-synuclein are emerging as key mediators of pathogenesis in
Parkinson's disease. Our understanding of the exact contribution of alpha-synuclein …