Phosphodiesterases are a diverse family of enzymes that hydrolyse cyclic nucleotides and
thus play a key role in regulating intracellular levels of the second messengers cAMP and …

Phosphodiesterase4 inhibitors are currently under development for the treatment of
respiratory diseases including asthma and chronic obstructive pulmonary disease. The …

Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and
asthma, affect millions of people all over the world. Cyclic adenosine monophosphate …

Phosphodiesterases (PDEs) are a family of enzymes which catalyse the metabolism of the
intracellular cyclic nucleotides, c-AMP and c-GMP that are expressed in a variety of cell …

Abstract Phosphodiesterase 4 (PDE4) belongs to a family of enzymes which catalyzes the
breakdown of 3, 5′-adenosine cyclic monophosphate (cAMP) and is ubiquitously …

Theophylline has been relegated to a second-or even third-line therapy in the treatment of
asthma and chronic obstructive pulmonary disease (COPD), behind glucocorticosteroids …

The chemistry of 1, 3, 4-thiadiazoles is very well known. A universal and commonly used
method of the synthesis of different 2, 5-disubstituted 1, 3, 4-thiadiazoles includes the …

Traumatic spinal cord injury (SCI) is characterized by severe neuroinflammation and
hampered neuroregeneration, which often leads to permanent neurological deficits. Current …

Phosphodiesterase (PDE) 4 inhibitors prevent the metabolism of cyclic adenosine
monophosphate, thereby reducing inflammation. Inhaled PDE4 inhibitors aim to restrict …

Xanthines like theophylline have long been recognised as being effective drugs for the
treatment of asthma and chronic obstructive pulmonary disease (COPD). They are of interest …