Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …

The health risks associated with transferring embryos classified as mosaic by
preimplantation genetic testing for aneuploidies (PGT-A) are currently unknown. Such …

Somatic evolution of cells within the body is well known to lead to cancers. However, spread
of somatic mutations within a tissue over time may also contribute to the pathogenesis of non …

Mosaicism refers to the occurrence of two or more genomes in an individual derived from a
single zygote. Germline mosaicism is a mutation that is limited to the gonads and can be …

Recent discoveries have shown that harboring cells without the Y chromosome in the
peripheral blood is associated with increased risk for all-cause mortality and disease such …

To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP
microarray intensity data of 38,303 women from cancer genome-wide association studies …

Background Understanding the biological differences between sexes in cancer is essential
for personalized treatment and prevention. We hypothesized that the extreme …

Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …

Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic architecture and biological mechanisms underlying mLOY are …

Background—Recent studies found an immune regulatory role for Y chromosome and a
relationship between loss of Y chromosome (LOY) in blood cells and a higher risk of cancer …