Mosaic loss of chromosome Y (mLOY) is the most common somatic alteration as men aging
and may reflect genome instability. PM exposure is a major health concern worldwide, but its …

Ample evidence exists for shared risk factors for genetic mosaicism and cancer risk as well
as abundant support linking genetic mosaicism in leukocytes to hematologic malignancies …

We now recognize that with aging, hematopoietic stem and progenitor cells (HSPCs)
acquire mutations that confer a fitness advantage and clonally expand in a process now …

Small cell lung cancer (SCLC) is a carcinoma of the lungs with strong invasion, poor
prognosis and resistant to multiple chemotherapeutic drugs. It has posed severe challenges …

The development of new biomarkers for prediction and early detection of human diseases,
as well as for monitoring the response to therapy is one of the most relevant areas of modern …

We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the
known risk factors for this condition. We then overview the associations between LOY and …

A diverse set of driver genes, such as regulators of DNA methylation, RNA splicing, and
chromatin remodeling, have been associated with pre-malignant clonal expansion of …

In the current issue of Haematologica, Ouseph et al. 1 pres-ent new results on the relation
between somatic Y chromosome loss and hematologic malignancies. Mosaic loss of …

Background Life expectancy is 10–20 years lower in patients with schizophrenia than in the
general population. In addition, men with schizophrenia have an earlier age at onset, more …

Our DNA is consistently assaulted by a variety of intrinsic and extrinsic mutational factors.
Fortunately, DNA repair provides for protective barriers that limit the full manifestation of …