Coined three decades ago, the term aptamer and directed evolution have now reached their
maturity. The concept that nucleic acid could modulate the activity of target protein as ligand …

The development of new drugs is time-consuming and expensive, and as such, accurately
predicting the potential toxicity of a drug candidate is crucial in ensuring its safety and …

Noncanonical nucleic acid structures, such as G-quadruplex (G4) and i-Motif (iM), have
attracted increasing research interests because of their unique structural and binding …

Significant improvements have been made in the efficiency and accuracy of RNA 3D
structure prediction methods during the succeeding challenges of RNA-Puzzles, a …

A series of fluorescein-encapsulated zeolitic imidazolate framework-8 (fluorescein@ ZIF-8)
luminescent nanoparticles with a scalable guest loading has been fabricated and …

In this research, we aimed to study the photocatalytic behavior of metal-polymer
nanocomposite materials. Au/ZnO nanoparticles were synthesized via co-precipitation and …

Sophisticated analysis and simplified visualization are crucial for understanding complicated
structures of biomacromolecules. DSSR (Dissecting the Spatial Structure of RNA) is an …

Numerous chemical compounds are distributed around the world and may affect the
homeostasis of the endocrine system by disrupting the normal functions of hormone …

Abstract DNA-RNA hybrid (DRH) duplexes play essential roles during the replication of DNA
and the reverse transcription of RNA viruses, and their flexibility is important for their …

The constitutive androstane receptor (CAR) plays pivotal roles in drug-induced liver injury
through the transcriptional regulation of drug-metabolizing enzymes and transporters. Thus …