Glutamate is the primary excitatory neurotransmitter in mammalian brain. Disturbances in
glutamate-mediated neurotransmission have been increasingly documented in a range of …

Among the various drug discovery methods, a very promising modern approach consists in
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …

A systematic in-silico study based on molecular modeling techniques was conducted on
thirty 3, 4-disubstituted pyrrolidine sulfonamides derivatives to identify the drug candidate for …

Summary The glycine transporter 1 (GlyT1) plays a crucial role in the regulation of both
inhibitory and excitatory neurotransmission by removing glycine from the synaptic cleft …

A recent development for the efficient and environmentally friendly synthesis of aliphatic
amines is the transition-metal-catalyzed redox-neutral coupling of an alcohol and an amine …

Schizophrenia is a severe neuropsychiatric disorder without adequate current treatment.
Recent theories of schizophrenia focus on disturbances of glutamatergic neurotransmission …

GPR55 is a G protein-coupled receptor activated by l-α-lysophosphatidylinositol and
suggested to have roles in pain signaling, bone morphogenesis, and possibly in vascular …

We describe the preparation and evaluation of a novel series of glycine transporter 1 (GlyT1)
inhibitors derived from a high-throughput screening hit. The SAR studies resulted in the …

D-Amino acid oxidase (DAAO) catalyzes the oxidative metabolism of D-amino acids
including D-serine, a full agonist at the allosteric glycine binding site of the NMDA receptor …

The hypofunction hypothesis of glutamatergic neurotransmission via N-methyl-D-aspartate
(NMDA) receptors in the pathophysiology of schizophrenia suggests that increasing NMDA …