Metabolic homeostasis in mammals is tightly regulated by the complementary actions of
insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

The ATP-sensitive potassium channel (KATP channel) couples blood levels of glucose to
insulin secretion from pancreatic β-cells. KATP channel closure triggers a cascade of events …

ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …

Congenital hyperinsulinism is a rare disease, but is the most frequent cause of persistent
and severe hypoglycaemia in early childhood. Hypoglycaemia caused by excessive and …

Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the
unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic …

Background: Hyperinsulinism (HI) due to dysregulation of pancreatic beta-cell insulin
secretion is the most common and most severe cause of persistent hypoglycemia in infants …

The G-protein-coupled receptor accessory protein MRAP2 is implicated in energy control in
rodents, notably via the melanocortin-4 receptor. Although some MRAP2 mutations have …

ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6. 2 potassium
channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin …

Background Diabetes always involves variable degrees of β-cell demise and malfunction
leading to insufficient insulin secretion. Besides clinical investigations, many research …