Metabolomics and lipidomics are new drivers of the omics era as molecular signatures and
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …

A primary goal of metabolomics studies is to fully characterize the small-molecule
composition of complex biological and environmental samples. However, despite advances …

The chemistry of copper and iron plays a critical role in normal brain function. A variety of
enzymes and proteins containing positively charged Cu+, Cu2+, Fe2+, and Fe3+ control key …

We report on modifications made to a Paul-type quadrupole ion trap mass spectrometer and
discuss its application in infrared ion spectroscopy experiments. Main modifications involve …

(MS) and MS-driven proteomics have continued to develop as the premier tools for
characterizing proteome composition, structure, and function. 2 The new era of proteomics …

Pioneering work by, among others, the groups of Hunt and Mann at the start of this century
opened up the era of mass spectrometry (MS)-based phosphoproteomics. 1− 3 Through …

Plasmonic metal nanostructures can concentrate incident optical fields in nanometer-sized
volumes, called hot spots. This leads to enhanced optical responses of molecules in such a …

As a major class of mammalian lipids, phosphatidylcholines (PCs) often contain mixtures of
structural isomers, resulting from different lipogenesis pathways. Profiling PCs at the isomer …

Peptide sequencing is of great significance to fundamental and applied research in the
fields such as chemical, biological, medicinal and pharmaceutical sciences. With the rapid …

In recent years, electron capture (ECD) and electron transfer dissociation (ETD) have
emerged as two of the most useful methods in mass spectrometry‐based protein analysis …