The biology of cancer exosomes: insights and new perspectives

CF Ruivo, B Adem, M Silva, SA Melo - Cancer research, 2017 - AACR
Exosomes are a subclass of extracellular vesicles involved in intercellular communication
that are released by all cell types, including cancer cells. Cancer exosomes carry malignant …

Tumor cell-derived exosomes: a message in a bottle

P Kharaziha, S Ceder, Q Li, T Panaretakis - Biochimica et Biophysica Acta …, 2012 - Elsevier
Exosomes constitute the newest mode of intercellular communication, transmitting
information between cells. This exchange of molecular information is facilitated by their …

[HTML][HTML] Exosomal proteins as diagnostic biomarkers in lung cancer

B Sandfeld-Paulsen, KR Jakobsen, R Bæk… - Journal of Thoracic …, 2016 - Elsevier
Introduction Exosomes have been suggested as promising biomarkers in NSCLC because
they contain proteins from their originating cells and are readily available in plasma. In this …

Identification of genes associated with non-small-cell lung cancer promotion and progression

J Bankovic, J Stojsic, D Jovanovic, T Andjelkovic… - Lung cancer, 2010 - Elsevier
Lung cancer is the most common cause of neoplasia-related death worldwide. One of the
crucial early events in carcinogenesis is the induction of genomic instability and mutator …

Systemic induction of the angiogenesis switch by the tetraspanin D6. 1A/CO-029

S Gesierich, I Berezovskiy, E Ryschich, M Zöller - Cancer research, 2006 - AACR
Expression of the tetraspanin CO-029 is associated with poor prognosis in patients with
gastrointestinal cancer. In a pancreatic tumor line, overexpression of the rat homologue, D6 …

The indicative value of serum tumor markers for metastasis and stage of non-small cell lung cancer

C Jiang, M Zhao, S Hou, X Hu, J Huang, H Wang… - Cancers, 2022 - mdpi.com
Simple Summary This study recruited 3272 non-small cell lung cancer (NSCLC) cases to
analyze the predictive abilities of serum tumor markers (CEA, SCC-Ag, CYFRA 21-1, NSE …

Progressive slowdown/prevention of cellular senescence by CD9-targeted delivery of rapamycin using lactose-wrapped calcium carbonate nanoparticles

RK Thapa, HT Nguyen, JH Jeong, JR Kim, HG Choi… - Scientific reports, 2017 - nature.com
Cellular senescence, a state of irreversible growth arrest and altered cell function, causes
aging-related diseases. Hence, treatment modalities that could target aging cells would …

CD9, a tetraspanin target for cancer therapy?

A Lorico, M Lorico-Rappa… - Experimental …, 2021 - journals.sagepub.com
In the present minireview, we intend to provide a brief history of the field of CD9 involvement
in oncogenesis and in the metastatic process of cancer, considering its potential value as a …

Balancing yield, purity and practicality: a modified differential ultracentrifugation protocol for efficient isolation of small extracellular vesicles from human serum

SM Langevin, D Kuhnell, MA Orr-Asman, J Biesiada… - RNA biology, 2019 - Taylor & Francis
Ultracentrifugation remains the gold standard for isolation of small extracellular vesicles
(sEV), particularly for cancer applications. The objective of this study was to determine if a …

Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies

S Detchokul, ED Williams, MW Parker… - British journal of …, 2014 - Wiley Online Library
One of the hallmarks of cancer is the ability to activate invasion and metastasis. Cancer
morbidity and mortality are largely related to the spread of the primary, localized tumour to …