Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Promotion of good mental health, prevention, and early intervention before/at the onset of
mental disorders improve outcomes. However, the range and peak ages at onset for mental …

Mental ill‐health represents the main threat to the health, survival and future potential of
young people around the world. There are indications that this is a rising tide of vulnerability …

Preventive approaches have latterly gained traction for improving mental health in young
people. In this paper, we first appraise the conceptual foundations of preventive psychiatry …

The network approach to psychopathology posits that mental disorders can be
conceptualized and studied as causal systems of mutually reinforcing symptoms. This …

The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …

Importance Detection, prognosis, and indicated interventions in individuals at clinical high
risk for psychosis (CHR-P) are key components of preventive psychiatry. Objective To …

Mental disorders frequently begin in childhood or adolescence. Psychotropic medications
have various indications for the treatment of mental disorders in this age group and are used …

Recognizing that current frameworks for classification and treatment in psychiatry are
inadequate, particularly for use in young people and early intervention services …

Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …