Cytochrome P450 enzymes are essential for the metabolism of many medications. Although
this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the …

Objective This study presents an updated meta-analysis of the effects of benzodiazepines
on cognitive functioning in long-term, current users of these agents, those who have recently …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Now in its fifth edition, this best-selling, multidisciplinary textbook continues to draw on the
skills of pharmacists and clinicians to present optimal drug regimens. The authors integrate …

Recent technologies have resulted in an explosion of information concerning the
cytochrome P‐450 isoenzymes and increased awareness of life‐threatening interactions' …

The proton pump inhibitors rabeprazole, omeprazole, lansoprazole, and pantoprazole
undergo an extensive hepatic biotransformation. In the liver, they are metabolized to varying …

Drug-drug interactions have become an important issue in health care. It is now realized that
many drug-drug interactions can be explained by alterations in the metabolic enzymes that …

Until recently, cardiac toxicity manifesting in the form of arrhythmias related to QT interval
prolongation was uncommonly appreciated within the antimicrobial class of drugs, but it was …

Second-generation histamine H 1 receptor antagonists (antihistamines) have been
developed to reduce or eliminate the sedation and anticholinergic adverse effects that occur …

Drug metabolism studies constitute an important and necessary step in the evaluation of
drug efficacy and safety. In vivo drug metabolism studies suffer from many disadvantages …