Current status of the diagnosis and management of osteoporosis

A Aibar-Almazán, A Voltes-Martínez… - International journal of …, 2022 - mdpi.com
Osteoporosis has been defined as the silent disease of the 21st century, becoming a public
health risk due to its severity, chronicity and progression and affecting mainly …

Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022 - Springer
Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

Molecular mechanisms and emerging therapeutics for osteoporosis

JY Noh, Y Yang, H Jung - International journal of molecular sciences, 2020 - mdpi.com
Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview

G Martemucci, P Portincasa, A Di Ciaula… - Mechanisms of Ageing …, 2022 - Elsevier
Aging is characterized by a progressive loss of tissue and organ function due to genetic and
environmental factors, nutrition, and lifestyle. Oxidative stress is one the most important …

[HTML][HTML] Recent advances in regenerative medicine strategies for cancer treatment

V Mansouri, N Beheshtizadeh, M Gharibshahian… - Biomedicine & …, 2021 - Elsevier
Cancer stands as one of the most leading causes of death worldwide, while one of the most
significant challenges in treating it is revealing novel alternatives to predict, diagnose, and …

NMR: unique strengths that enhance modern metabolomics research

AS Edison, M Colonna, GJ Gouveia… - Analytical …, 2020 - ACS Publications
Nuclear magnetic resonance (NMR) spectroscopy is an important analytical technique in
metabolomics. Because it provides atomic-level detail of small molecules, NMR is …

Mesenchymal stem cells as a cornerstone in a galaxy of intercellular signals: basis for a new era of medicine

S Fernández-Francos, N Eiro, LA Costa… - International journal of …, 2021 - mdpi.com
Around 40% of the population will suffer at some point in their life a disease involving tissue
loss or an inflammatory or autoimmune process that cannot be satisfactorily controlled with …

Bone regeneration in osteoporosis: opportunities and challenges

D Patel, S Wairkar - Drug Delivery and Translational Research, 2023 - Springer
Osteoporosis is a bone disorder characterised by low bone mineral density, reduced bone
strength, increased bone fragility, and impaired mineralisation of bones causing an …

METTL3‐m6A methylase regulates the osteogenic potential of bone marrow mesenchymal stem cells in osteoporotic rats via the Wnt signalling pathway

T Wu, H Tang, J Yang, Z Yao, L Bai, Y Xie, Q Li… - Cell …, 2022 - Wiley Online Library
Objectives Bone marrow mesenchymal stem cells (BMSCs) hold a high osteogenic
differentiation potential, but the mechanisms that control the osteogenic ability of BMSCs …

The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesis

S Bathina, R Armamento-Villareal - Frontiers in endocrinology, 2023 - frontiersin.org
Fractures associated with Type2 diabetes (T2DM) are major public health concerns in an
increasingly obese and aging population. Patients with obesity or T2DM have normal or …