Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

Cholesterol transport between intracellular compartments proceeds by both energy-and non-
energy-dependent processes. Energy-dependent vesicular traffic partly contributes to …

Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …

A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of
GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) …

Gastric cancer is one of the most frequent and lethal malignancies worldwide because of
high frequency of metastasis. Tumor cell motility and invasion play fundamental roles in …

Abstract Significance: The 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors or
statins are important therapeutic agents for lowering serum cholesterol levels. However …

The dysfunctions of human umbilical vein endothelial cells (HUVECs) are important features
of atherosclerosis (AS). Circular RNAs (circRNAs) are regulators of a wide range of human …

Hyperglycemia has been shown to accelerate atherogenesis, an inflammation process
resulting from macrophage activation. Although high glucose (HG) was previously …