The dysfunctions of human umbilical vein endothelial cells (HUVECs) are important features
of atherosclerosis (AS). Circular RNAs (circRNAs) are regulators of a wide range of human …

Small GTP ases of the R ho family and their down‐stream effectors R ho associated kinases
(ROCKs) are the molecules that converge a spectrum of pathophysiological signals …

Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase
that was originally identified as RhoA interacting protein. A diverse array of cellular …

Niemann–Pick disease type C1 (NPC1) is a rare, prematurely fatal lysosomal storage
disorder which exhibits highly variable severity and disease progression as well as a wide …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and is
strongly associated with cardiovascular mortality. Given the pandemic of obesity and …

Cholesterol accumulation is a critical step during the development and progression of
atherosclerosis. Recently, Wnt5a expression has been found to be markedly upregulated in …

Aims Rho-associated coiled-coil containing kinase (ROCK)-2 is an important mediator of the
actin cytoskeleton. Because changes in the actin cytoskeleton are critical for platelet …

Background Erectile dysfunction (ED) is a common clinical condition with limited treatment
options. The main aim of the present systematic review was to synthesize information on …

Objectives—Monocyte/macrophage recruitment and activation at vascular predilection sites
plays a central role in the pathogenesis of atherosclerosis. Heterotrimeric G proteins of the …

Abstract Apabetalone (RVX-208) inhibits the interaction between epigenetic regulators
known as bromodomain and extraterminal (BET) proteins and acetyl-lysine marks on …