Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant
physiological and pharmacological effects. In this review we summarize data from numerous …

Chronic pain is a common symptom experienced during cancer progression. Additionally,
some patients experience bone pain caused by cancer metastasis, which further …

Cancers of the digestive tract are among the most prevalent types of cancer. These types of
cancers are often diagnosed at a late stage, which results in a poor prognosis. Currently …

Severe pain is often experienced by patients with head and neck cancer and is associated
with a poor prognosis. Despite its frequency and severity, current treatments fail to …

Oral cancer patients report sensitivity to spicy foods and liquids. The mechanism responsible
for chemosensitivity induced by oral cancer is not known. We simulate oral cancer-induced …

Head and neck cancer (HNC) affects over 890,000 people annually worldwide and has a
mortality rate of 50%. Aside from poor survival, HNC pain impairs eating, drinking, and …

The 5-year survival rate for oral squamous cell carcinoma (OSCC), one of the most common
head and neck cancers, has not improved in the last 20 years. Poor prognosis of OSCC is …

1. Background Quality of life of patients with head and neck cancer (HNC) is notoriously
poor because of the greater prevalence of pain compared with other cancer types. 15, 42 …

The majority of patients with oral cancer report intense pain that is only partially managed by
current analgesics. Thus, there is a strong need to study mechanisms as well as develop …

To evaluate the effects of allicin on mediators of pain secreted by oral cancer cells in vitro,
single-cell suspensions were prepared by enzymatic method from oral squamous cell …