Structural and functional diversity of type IV secretion systems

TRD Costa, JB Patkowski, K Macé, PJ Christie… - Nature Reviews …, 2024 - nature.com
Considerable progress has been made in recent years in the structural and molecular
biology of type IV secretion systems in Gram-negative bacteria. The latest advances have …

Type IV secretion systems: advances in structure, function, and activation

TRD Costa, L Harb, P Khara, L Zeng, B Hu… - Molecular …, 2021 - Wiley Online Library
Bacterial type IV secretion systems (T4SSs) are a functionally diverse translocation
superfamily. They consist mainly of two large subfamilies:(i) conjugation systems that …

Type IV secretion in Gram‐negative and Gram‐positive bacteria

E Grohmann, PJ Christie, G Waksman… - Molecular …, 2018 - Wiley Online Library
Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the
entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important …

Towards an integrated model of bacterial conjugation

E Cabezón, J Ripoll-Rozada, A Peña… - FEMS microbiology …, 2015 - academic.oup.com
Bacterial conjugation is one of the main mechanisms for horizontal gene transfer. It
constitutes a key element in the dissemination of antibiotic resistance and virulence genes to …

[HTML][HTML] Mechanism and structure of the bacterial type IV secretion systems

PJ Christie, N Whitaker, C González-Rivera - Biochimica et Biophysica Acta …, 2014 - Elsevier
The bacterial type IV secretion systems (T4SSs) translocate DNA and protein substrates to
bacterial or eukaryotic target cells generally by a mechanism dependent on direct cell-to-cell …

From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective

G Waksman - EMBO reports, 2019 - embopress.org
Conjugation is the process by which bacteria exchange genetic materials in a unidirectional
manner from a donor cell to a recipient cell. The discovery of conjugation signalled the dawn …

The mosaic type IV secretion systems

PJ Christie - EcoSal Plus, 2016 - Am Soc Microbiol
Escherichia coli and other Gram-negative and-positive bacteria employ type IV secretion
systems (T4SSs) to translocate DNA and protein substrates, generally by contact-dependent …

Structural biology of the Gram-negative bacterial conjugation systems

A Ilangovan, S Connery, G Waksman - Trends in microbiology, 2015 - cell.com
Conjugation, the process by which plasmid DNA is transferred from one bacterium to
another, is mediated by type IV secretion systems (T4SSs). T4SSs are versatile systems that …

[HTML][HTML] Secrete or perish: the role of secretion systems in Xanthomonas biology

CE Alvarez-Martinez, GG Sgro, GG Araujo… - Computational and …, 2021 - Elsevier
Bacteria of the Xanthomonas genus are mainly phytopathogens of a large variety of crops of
economic importance worldwide. Xanthomonas spp. rely on an arsenal of protein effectors …

[HTML][HTML] Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes

A Meir, K Macé, Y Vegunta, SM Williams… - Trends in …, 2023 - cell.com
Bacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact
with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting …