ATPases associated with diverse cellular activities (AAA+ proteins) are macromolecular
machines that convert the chemical energy contained in ATP molecules into powerful …

AAA+ family proteolytic machines (ClpXP, ClpAP, ClpCP, HslUV, Lon, FtsH, PAN/20S, and
the 26S proteasome) perform protein quality control and are used in regulatory circuits in all …

À medida que a quantidade de informações em biologia aumenta exponencialmente, é
cada vez mais importante que os livros tenham a capacidade de transformar grandes …

Visualizing biomolecular and cellular processes inside intact living organisms is a major
goal of chemical biology. However, existing molecular biosensors, based primarily on …

October 1, 1905 (1). Today, after more than 100 years and 350,000 articles on these
enzymes in the scientific literature, proteases remain at the cutting edge of biological …

ClpXP is a AAA+ protease that uses the energy of ATP binding and hydrolysis to perform
mechanical work during targeted protein degradation within cells. ClpXP consists of …

In living cells, both newly made and preexisting polypeptide chains are at constant risk for
misfolding and aggregation. In accordance with the wide diversity of misfolded forms …

In the cell, proteins are synthesized from N to C terminus and begin to fold during translation.
Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as …

A healthy proteome is essential for cell survival. Protein misfolding is linked to a rapidly
expanding list of human diseases, ranging from neurodegenerative diseases to aging and …

The AAA+ (ATPases associated with various cellular activities) family is a large and
functionally diverse group of enzymes that are able to induce conformational changes in a …