Glutamate is the principal excitatory neurotransmitter in brain. Our knowledge of the
glutamatergic synapse has advanced enormously in the last 10 years, primarily through …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Introduction. The amino acid glutamate is present in high concentrations in the mammalian
brain, and it acts as the major excitatory neurotransmitter in the CNS. Through its actions on …

In the progress of science, as in life, timing is important. The acidic dipeptide, N‐
acetylaspartylglutamate (NAAG), was discovered in the mammalian nervous system in 1965 …

The neuropeptidase glutamate carboxypeptidase II (GCPII) hydrolyzes N-acetyl-l-aspartyl-l-
glutamate (NAAG) to liberate N-acetylaspartate and glutamate. GCPII was originally cloned …

Modulation of N-acetyl-l-aspartyl-l-glutamate peptidase activity with small-molecule
inhibitors holds promise for a wide variety of diseases that involve glutamatergic …

The medium collected from cultured astrocytes transiently exposed to the group-II
metabotropic glutamate (mGlu) receptor agonists (2S, 1′ R, 2′ R, 3′ R)-2-(2, 3 …

Dual metabotropic glutamate 2/3 (mGlu2/3) receptor agonists have been examined with
success in the clinic with positive proof of efficacy in several tests of anxiety and …

Group II metabotropic glutamate receptors (mGluRs) comprise mGluR2 (mGlu2; encoded by
GRM2) and mGluR3 (mGlu3; encoded by GRM3) and modulate glutamate …

Phencyclidine (PCP) administration elicits positive and negative symptoms that resemble
those of schizophrenia and is widely accepted as a model for the study of this human …