[HTML][HTML] Host-directed therapies: modulating inflammation to treat tuberculosis

S Krug, S Parveen, WR Bishai - Frontiers in immunology, 2021 - frontiersin.org
Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …

Drug-resistant tuberculosis 2020: where we stand

A Iacobino, L Fattorini, F Giannoni - Applied Sciences, 2020 - mdpi.com
Featured Application This comprehensive overview of drug-resistant tuberculosis will be
useful for researchers to expand their knowledge beyond mechanisms other than …

The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis

BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …

[HTML][HTML] Delamanid-containing regimens and multidrug-resistant tuberculosis: A systematic review and meta-analysis

MJ Nasiri, M Zangiabadian, E Arabpour, S Amini… - International Journal of …, 2022 - Elsevier
Introduction Multidrug-resistant tuberculosis (MDR-TB) is a life-threatening condition
needing long poly-chemotherapy regimens. As no systematic reviews/meta-analysis is …

The changing paradigm of drug-resistant tuberculosis treatment: successes, pitfalls, and future perspectives

N Dookie, SL Ngema, R Perumal… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Drug-resistant tuberculosis (DR-TB) remains a global crisis due to the increasing incidence
of drug-resistant forms of the disease, gaps in detection and prevention, models of care, and …

Antibiotic approvals in the last decade: are we keeping up with resistance?

EB Chahine, JA Dougherty… - Annals of …, 2022 - journals.sagepub.com
Objective: To review the spectrum of activity, efficacy, safety, and role in therapy of all
antibiotics and related biologics approved by the Food and Drug Administration (FDA) in the …

[HTML][HTML] Availability and costs of medicines for the treatment of tuberculosis in Europe

G Günther, L Guglielmetti, C Leu, C Lange… - Clinical microbiology …, 2023 - Elsevier
Objectives To evaluate the access to comprehensive diagnostics and novel antituberculosis
medicines in European countries. Methods We investigated the access to genotypic and …

Acquired bedaquiline resistance during the treatment of drug-resistant tuberculosis: a systematic review

JS Mallick, P Nair, ET Abbew… - JAC-antimicrobial …, 2022 - academic.oup.com
Background Drug-resistant tuberculosis (DR-TB) is considered to be a public health threat
and is difficult to cure, requiring a lengthy treatment with potent, potentially toxic drugs. The …

[HTML][HTML] Essential components of a public health tuberculosis prevention, control, and elimination program: recommendations of the Advisory Council for the …

B Cole - MMWR. Recommendations and Reports, 2020 - cdc.gov
This report provides an introduction and reference tool for tuberculosis (TB) controllers
regarding the essential components of a public health program to prevent, control, and …

Bedaquiline-resistant tuberculosis: dark clouds on the horizon

S Andres, M Merker, J Heyckendorf… - American journal of …, 2020 - atsjournals.org
Methods In June 2018, BDQ and CFZ were added to the second-line phenotypic drug
susceptibility testing (pDST) panel at the National and WHO Supranational Reference …