Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …

Metabolomics allows the simultaneous and relative quantification of thousands of different
metabolites within a given sample using sensitive and specific methodologies such as gas …

1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …

We present a comprehensive overview of the hierarchical network of intracellular processes
revolving around central nitrogen metabolism in Escherichia coli. The hierarchy intertwines …

Background The elucidation of complex biological systems requires integration of multiple
molecular parameters. Accordingly, high throughput methods like transcriptomics …

Over recent years, fluorescent probes exhibiting simultaneous responses to multiple targets
have been developed for in situ, real-time monitoring of cellular metabolism using two …

Physiological variability manifests itself via differences in physiological function between
individuals of the same species, and has crucial implications in disease progression and …

Thanks to the contributions of scientists like Bert Vallee, zinc enzymology is an area of
research with a rich history and a strong basis of biochemical and biophysical knowledge. In …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on
the binding parameters that govern the interactions between T cell receptors (TCRs) and …