Maximizing the information content of experiments in systems biology

J Liepe, S Filippi, M Komorowski… - PLoS computational …, 2013 - journals.plos.org
Our understanding of most biological systems is in its infancy. Learning their structure and
intricacies is fraught with challenges, and often side-stepped in favour of studying the …

Physiology of mycobacteria

GM Cook, M Berney, S Gebhard, M Heinemann… - Advances in microbial …, 2009 - Elsevier
Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has
achieved a spread in the human population that is unmatched by any other bacterial …

Simultaneous tracking of autophagy and oxidative stress during stroke with an ICT-TBET integrated ratiometric two-photon platform

W Hu, T Qiang, L Chai, T Liang, L Ren, F Cheng… - Chemical …, 2022 - pubs.rsc.org
Over recent years, fluorescent probes exhibiting simultaneous responses to multiple targets
have been developed for in situ, real-time monitoring of cellular metabolism using two …

Minimal out-of-equilibrium metabolism for synthetic cells: a membrane perspective

E Bailoni, M Partipilo, J Coenradij… - ACS Synthetic …, 2023 - ACS Publications
Life-like systems need to maintain a basal metabolism, which includes importing a variety of
building blocks required for macromolecule synthesis, exporting dead-end products, and …

Regulation by transcription factors in bacteria: beyond description

E Balleza, LN Lopez-Bojorquez… - FEMS microbiology …, 2008 - academic.oup.com
Transcription is an essential step in gene expression and its understanding has been one of
the major interests in molecular and cellular biology. By precisely tuning gene expression …

Chinese herbs as alternatives to antibiotics in feed for swine and poultry production: potential and challenges in application

J Gong, F Yin, Y Hou, Y Yin - Canadian Journal of Animal …, 2014 - cdnsciencepub.com
Gong, J., Yin, F., Hou, Y. and Yin, Y. 2014. Chinese herbs as alternatives to antibiotics in
feed for swine and poultry production: Potential and challenges in application. Can. J. Anim …

Process analytical technology (PAT) for biopharmaceuticals

J Glassey, K Gernaey, C Clemens, TW Schulz… - Biotechnology …, 2011 - orbit.dtu.dk
Process analytical technology (PAT), the regulatory initiative for building in quality to
pharmaceutical manufacturing, has a great potential for improving biopharmaceutical …

Reductionistic and holistic science

FC Fang, A Casadevall - Infection and immunity, 2011 - Am Soc Microbiol
ABSTRACT A reductionistic approach to science, epitomized by molecular biology, is often
contrasted with the holistic approach of systems biology. However, molecular biology and …

Massive computational acceleration by using neural networks to emulate mechanism-based biological models

S Wang, K Fan, N Luo, Y Cao, F Wu, C Zhang… - Nature …, 2019 - nature.com
For many biological applications, exploration of the massive parametric space of a
mechanism-based model can impose a prohibitive computational demand. To overcome …

Advances in cardiovascular biomarker discovery

CM Ghantous, L Kamareddine, R Farhat, FA Zouein… - Biomedicines, 2020 - mdpi.com
Cardiovascular diseases are the leading causes of mortality worldwide. Among them,
hypertension and its pathological complications pose a major risk for the development of …