Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-
lymphoid tissues at sites of chronic inflammation including tumours. Key common …

The highly complex and heterogenous ecosystem of a tumour not only contains malignant
cells, but also interacting cells from the host such as endothelial cells, stromal fibroblasts …

The characterization of the microenvironment of human tumors led to the description of
tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T‐cell zone …

Purpose: The efficacy of PD-1 checkpoint blockade as adjuvant therapy in localized clear
cell renal cell carcinoma (ccRCC) is currently unknown. The identification of tumor …

Multiple studies have described associations between infiltrating immune cells and
prognosis in cancer; however, the clinical relevance has most often been attributed to the T …

Current therapies against cancer utilize the patient's immune system for tumor eradication.
However, tumor cells can evade immune surveillance of CD8+ T and/or natural killer (NK) …

Background The presence of tumor infiltrating lymphocytes (TIL) is associated with favorable
prognosis. Recent evidence suggested that not only their density, but also the spatial …

This study assessed the prognostic value of pre-treatment neutrophil-to-lymphocyte ratio
(NLR) in patients with metastatic solid tumors. Clinical and biological data for patients with …

Glucose metabolism and systemic inflammation have been associated with cancer
aggressiveness and patient prognosis in various malignancies. This study aimed to evaluate …

Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain
Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and …