Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Abstract Heme-oxygenase 1 (HO-1) is an inducible enzyme known for its anti-inflammatory,
antioxidant and neuroprotective effects. However, increased expression of HO-1 during …

The major hurdle in understanding Alzheimer's disease (AD) is a lack of knowledge about
the etiology and pathogenesis of selective neuron death. In recent years, considerable data …

The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Recently, we demonstrated a significant increase of an oxidized nucleoside derived from
RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable …

Under stressful conditions, cellular heme catabolism to carbon monoxide, iron and biliverdin
is mediated by the 32 kDa enzyme, heme oxygenase-1 (HO-1). A wide range of pro-oxidant …

Damage from free radicals has been demonstrated in susceptible neuronal populations in
cases of Alzheimer disease. In this study, we investigated whether iron, a potent source of …

Neurodegenerative disorders are characterized by extensive neuron death that leads to
functional decline, but the neurobiological correlates of functional decline in normal aging …

Research in the field of molecular biology has helped to provide a better understanding of
both the cascade of biochemical events that occurs with Alzheimer disease (AD) and the …