The pathogenesis of cardiovascular disease (CVD) is complex and multifactorial, and
inflammation plays a central role. Inflammasomes are multimeric protein complexes that are …

Obesity (especially visceral adiposity) can be associated with 3 different phenotypes of heart
failure: heart failure with a reduced ejection fraction, heart failure with a preserved ejection …

Background An enhanced inflammatory response predicts worse outcomes in heart failure
(HF). We hypothesized that administration of IL-1 (interleukin-1) receptor antagonist …

Abstract Interleukin-1 (IL-1) is the prototypical pro-inflammatory cytokine. IL-1 was implicated
as a cardiodepressant factor in septic shock, and subsequent pre-clinical and clinical …

Background Enhanced inflammation may lead to exercise intolerance in heart failure with
preserved ejection fraction. The aim of the current study was to determine whether IL …

Inflammatory activation is increasingly recognized as a nonconventional risk factor for
arrhythmias, and experimental studies provided robust evidence that this association is …

Cardiovascular diseases are the leading cause of death worldwide. Research in the last two
decades has emphasized the inflammatory process as a key component in the …

The NLRP3 inflammasome has been implicated in the development and progression of
heart failure. The aim of this study was to determine the safety of an oral inhibitor of the …

Vascular disease was for a long time considered a disease of the old age, but it is becoming
increasingly clear that a cumulus of factors can cause early vascular aging (EVA) …

Inflammation promotes the development of heart failure (HF). The inflammasome is a
multimeric protein complex that plays an essential role in the innate immune response by …