Histone deacetylase (HDAC) enzymes play crucial roles in epigenetic gene expression and
are an attractive therapeutic target. Five HDAC inhibitors have been approved for cancer …

Breast cancer (BC) is one of the main types of cancer that endangers women's lives. The
characteristics of triple-negative breast cancer (TNBC) include a high rate of recurrence and …

Microtubules are noncovalent polymers built from αβ-tubulin dimers. The disordered C-
terminal tubulin tails are functionalized with multiple glutamate chains of variable lengths …

Abstract Human histone deacetylase 6 (HDAC6) is the major deacetylase responsible for
removing the acetyl group from Lys40 of α-tubulin (αK40), which is located lumenally in …

Valproic acid (VPA) is a compound currently used in clinical practice for the treatment of
epilepsy as well as bipolar and mood disorders. VPA targets histone deacetylases (HDACs) …

The cytoskeleton plays important roles in many essential processes at the cellular and
organismal levels, including cell migration and motility, cell division, and the establishment …

Histone deacetylase 6 (HDAC6) is emerging as a target for inhibition in therapeutic
strategies aimed at treating cancer, neurodegenerative disease, and other disorders. Among …

Selective inhibition of histone deacetylase 6 (HDAC6) is being recognized as a therapeutic
approach for cancers. In this study, we designed a new HDAC6 inhibitor, named Suprastat …

Aim To investigate the role of histone deacetylase 6 (HDAC6) deacetylation activity in
nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) …

Isoform-selective histone deacetylase (HDAC) inhibition is promoted as a rational strategy to
develop safer anti-cancer drugs compared to non-selective HDAC inhibitors. Despite this …