Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there
are no effective treatments or cures. Herein, we report on a tetrahydroquinoline-based …

Viruses are obligatory cellular parasites. Their mission is to enter a host cell, to transfer the
viral genome, and to replicate progeny whilst diverting cellular immunity. The role of …

The dysregulation of histone deacetylases (HDACs) is closely associated with
tumorigenesis and has emerged as a promising target for anti-cancer drugs. Some odd …

Abstract Histone deacetylase 6 (HDAC6) is a zinc-dependent HDAC that mainly modulates
the acetylation status of non-histone substrates, such as α-tubulin and heat shock protein 90 …

Epigenetic modifiers of the histone deacetylase (HDAC) family contribute to autoimmunity,
cancer, HIV infection, inflammation, and neurodegeneration. Hence, histone deacetylase …

Influenza viruses are respiratory pathogens that represent a significant threat to public
health, despite the large-scale implementation of vaccination programs. It is necessary to …

HDAC6, a member of the histone deacetylase family, mainly is a cytosolic protein and
regulates cell growth by acting on non-histone substrates, such as α-tubulin, cortactin, heat …

Histone deacetylase (HDAC) 6 exists exclusively in cytoplasm and deacetylates cytoplasmic
proteins such as α-tubulin. HDAC6 dysfunction is associated with several pathological …

Inhibition of histone deacetylase 6 (HDAC6) has emerged as a promising therapeutic
strategy for the treatment of cancer, chemotherapy-induced peripheral neuropathy, and …

We have identified chemical probes that act as dual phosphodiesterase 5 (PDE5) and
histone deacetylase 6 (HDAC6)-selective inhibitors (> 1 log unit difference versus class I …