Influenza A virus (IAV) is an enveloped virus of the Orthomyxoviridae with a negative-sense
single-stranded RNA genome. During virus cell entry, viral and cellular cues are delivered in …

Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that
has the potential to infect humans. Histone deacetylase 6 (HDAC6) is a unique type IIb …

This paper describes the rational development of a series of novel spiroindoline derivatives
endowed with selective inhibitory activity on the HDAC6 isoform. A convenient …

Epigenetic regulation of genes through posttranslational regulation of proteins is a well‐
explored approach for disease treatment, particularly in cancer chemotherapy. Histone …

Worldwide, cancer is the second leading cause of mortality after cardiovascular diseases.
Among the numerous malignant tumors in human, digestive system cancers are the primary …

The deacetylase HDAC6 has tandem catalytic domains and a zinc finger domain (ZnF)
binding ubiquitin (Ub). While the catalytic domain has an antiviral effect, the ZnF facilitates …

Protein acetylation is an important contributor to cancer initiation. Histone deacetylase 6
(HDAC6) controls JAK2 translation and protein stability and has been implicated in JAK2 …

Colorectal cancer (CRC) comprises a heterogeneous group of gastrointestinal tract tumors.
It is a multifactorial disease, and a plethora of distinct factors are involved in its pathogenesis …

The multicomponent synthesis of a mini-library of histone deacetylase inhibitors with
imidazo [1, 2-a] pyridine-based cap groups is presented. The biological evaluation led to the …

The high number of failed pre-clinical and clinical studies for compounds targeting
Alzheimer disease (AD) has demonstrated that there is a need to reassess existing …