The suprachiasmatic nucleus (SCN) of the hypothalamus is remarkable. Despite numbering
only about 10,000 neurons on each side of the third ventricle, the SCN is our principal …

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …

Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

To characterize the role of the circadian clock in mouse physiology and behavior, we used
RNA-seq and DNA arrays to quantify the transcriptomes of 12 mouse organs over time. We …

The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …

Factors other than age and genetics may increase the risk of developing Alzheimer disease
(AD). Accumulation of the amyloid-β (Aβ) peptide in the brain seems to initiate a cascade of …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

The sleep–wake cycle and circadian rhythmicity both contribute to brain function, but
whether this contribution differs between men and women and how it varies across cognitive …

The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …

Nighttime restlessness and daytime drowsiness are common and early symptoms of
Alzheimer's Disease (AD). This symptomology implicates dysfunctional biological timing, yet …