Reduced FSH and LH action: implications for medically assisted reproduction

E Bosch, C Alviggi, M Lispi, A Conforti… - Human …, 2021 - academic.oup.com
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play complementary roles
in follicle development and ovulation via a complex interaction in the hypothalamus, anterior …

Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual …

A Capalbo, M Poli, A Riera-Escamilla… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND Our genetic code is now readable, writable and hackable. The recent
escalation of genome-wide sequencing (GS) applications in population diagnostics will not …

[HTML][HTML] Recent advances in understanding gonadotropin signaling

L Casarini, M Simoni - Faculty reviews, 2021 - ncbi.nlm.nih.gov
Gonadotropins are glycoprotein sex hormones regulating development and reproduction
and bind to specific G protein–coupled receptors expressed in the gonads. Their effects on …

Updates in diagnosing polycystic ovary syndrome-related infertility

H Haddad-Filho, JAG Tosatti, FM Vale… - Expert Review of …, 2023 - Taylor & Francis
Introduction Polycystic ovary syndrome (PCOS) is a condition that affects approximately 13%
of reproductive age women and is characterized by androgen excess, menstrual irregularity …

Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity

H Mbarek, SD Gordon, DL Duffy, N Hubers… - Human …, 2024 - academic.oup.com
STUDY QUESTION Which genetic factors regulate female propensity for giving birth to
spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci …

[HTML][HTML] Effect of genetic variants of gonadotropins and their receptors on ovarian stimulation outcomes: a delphi consensus

A Conforti, F Tüttelmann, C Alviggi, HM Behre… - Frontiers in …, 2022 - frontiersin.org
Background A Delphi consensus was conducted to evaluate the influence of single
nucleotide polymorphisms (SNPs) in genes encoding gonadotropin and gonadotropin …

[HTML][HTML] Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis

B Bianco, FA Loureiro, CM Trevisan… - Frontiers in …, 2021 - frontiersin.org
Background Single nucleotide variants (SNVs) FSHB: c.-211G> T, FSHR: c. 919G> A, and
FSHR: c. 2039G> A were reported to be associated with the variability in FSH and LH levels …

[HTML][HTML] Low prognosis by the POSEIDON criteria in women undergoing assisted reproductive technology: a multicenter and multinational prevalence study of over …

SC Esteves, H Yarali, LN Vuong, JF Carvalho… - Frontiers in …, 2021 - frontiersin.org
Objective To estimate the prevalence of low-prognosis patients according to the POSEIDON
criteria using real-world data. Design Multicenter population-based cohort study. Settings …

The effect of polymorphisms in FSHR gene on late follicular phase progesterone and estradiol serum levels in predicted normoresponders

AR Neves, NL Vuong, C Blockeel, S Garcia… - Human …, 2022 - academic.oup.com
STUDY QUESTION Does the presence of FSHR single-nucleotide polymorphisms (SNPs)
affect late follicular phase progesterone and estradiol serum levels in predicted …

[HTML][HTML] Recombinant human follicle-stimulating hormone alfa dose adjustment in us clinical practice: an observational, retrospective analysis of a real-world …

MC Mahony, B Hayward, GL Mottla… - Frontiers in …, 2021 - frontiersin.org
Purpose To determine the pattern of dose adjustment of recombinant human follicle-
stimulating hormone alfa (r-hFSH-alfa) during ovarian stimulation (OS) for assisted …