The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Although the subcellular dynamics of RNA and proteins are key determinants of cell
homeostasis, their characterization is still challenging. Here we present an integrative …

RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins
propagate signals only when associated with cellular membranes as a consequence of lipid …

Eukaryotic cells possess hundreds of protein complexes that contain multiple subunits and
must be formed at the correct time and place during development. Despite specific assembly …

We previously demonstrated that a subset of acute myeloid leukemia (AML) patients with
concurrent RAS pathway and TP53 mutations have an extremely poor prognosis and that …

Objective Osteoarthritis (OA) is one of the most common degenerative joint diseases and is
associated with autophagy suppression. However, the molecular mechanism of autophagy …

The cell cycle is tightly regulated by protein phosphorylation and ubiquitylation events.
During mitosis, the multi-subunit cullin-RING E3 ubiquitin ligase APC/c functions as a …

Background Adult hematopoietic stem cells (HSCs) homeostasis is critically important in
maintaining lifelong hematopoiesis. However, how adult HSCs orchestrate its homeostasis …

Viruses are strictly intracellular parasites requiring host cellular functions to complete their
reproduction cycle involving virus infection of host cell, viral genome replication, viral protein …