Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Progressive obstructive lung disease secondary to chronic airway infection, coupled with
impaired host immunity, is the leading cause of morbidity and mortality in cystic fibrosis (CF) …

Staphylococcus aureus is a predominant cause of chronic lung infections. While the airway
environment is rich in highly sialylated mucins, the interaction of S. aureus with sialic acid is …

Objective Pseudomonas aeruginosa is an opportunistic pathogen that infects the lungs of
people with cystic fibrosis (CF) and is the most common cause of chronic respiratory …

Cystic Fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene
encoding for the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein …

Cystic fibrosis is an autosomal recessive genetic disease, mainly in Caucasian children and
young adults. It is caused by pathogenic variants in the CFTR (cystic fibrosis transmembrane …

Cystic fibrosis (CF) is one of the most prevalent lethal genetic diseases with over 2000
identified mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) …

Chronic respiratory infection (CRI) with Pseudomonas aeruginosa (Pa) presents many
unique challenges that complicate treatment. One notable challenge is the hypermutator …

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators, a new series of
therapeutics that correct and potentiate some classes of mutations of the CFTR, have …

Pulmonary ionocytes express high levels of cystic fibrosis transmembrane conductance
regulator (CFTR), an anion channel that is critical for hydration of the airways and …