An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
Microbial epidemiology of the cystic fibrosis airways: past, present, and future
CS Thornton, MD Parkins - Seminars in Respiratory and …, 2023 - thieme-connect.com
Progressive obstructive lung disease secondary to chronic airway infection, coupled with
impaired host immunity, is the leading cause of morbidity and mortality in cystic fibrosis (CF) …
impaired host immunity, is the leading cause of morbidity and mortality in cystic fibrosis (CF) …
Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle
X Ding, C Robbe-Masselot, X Fu, R Léonard… - Nature …, 2023 - nature.com
Staphylococcus aureus is a predominant cause of chronic lung infections. While the airway
environment is rich in highly sialylated mucins, the interaction of S. aureus with sialic acid is …
environment is rich in highly sialylated mucins, the interaction of S. aureus with sialic acid is …
Prevalence of antibiotic resistance of Pseudomonas aeruginosa in cystic fibrosis infection: A systematic review and meta-analysis
P Bonyadi, NT Saleh, M Dehghani, M Yamini… - Microbial …, 2022 - Elsevier
Objective Pseudomonas aeruginosa is an opportunistic pathogen that infects the lungs of
people with cystic fibrosis (CF) and is the most common cause of chronic respiratory …
people with cystic fibrosis (CF) and is the most common cause of chronic respiratory …
CFTR modulator therapies: potential impact on airway infections in cystic fibrosis
F Saluzzo, L Riberi, B Messore, NI Loré, I Esposito… - Cells, 2022 - mdpi.com
Cystic Fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene
encoding for the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein …
encoding for the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein …
[HTML][HTML] Cystic fibrosis: current concepts
JA López-Valdez, LA Aguilar-Alonso… - Boletín médico del …, 2021 - scielo.org.mx
Cystic fibrosis is an autosomal recessive genetic disease, mainly in Caucasian children and
young adults. It is caused by pathogenic variants in the CFTR (cystic fibrosis transmembrane …
young adults. It is caused by pathogenic variants in the CFTR (cystic fibrosis transmembrane …
Elexacaftor/VX-445–mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics
M Kim, EF McDonald, CMP Sabusap… - Journal of Biological …, 2023 - ASBMB
Cystic fibrosis (CF) is one of the most prevalent lethal genetic diseases with over 2000
identified mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) …
identified mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) …
The role of the Pseudomonas aeruginosa hypermutator phenotype on the shift from acute to chronic virulence during respiratory infection
KM Hall, ZF Pursell, LA Morici - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Chronic respiratory infection (CRI) with Pseudomonas aeruginosa (Pa) presents many
unique challenges that complicate treatment. One notable challenge is the hypermutator …
unique challenges that complicate treatment. One notable challenge is the hypermutator …
Revisiting host-pathogen interactions in cystic fibrosis lungs in the era of CFTR modulators
CMP Ribeiro, MG Higgs, MS Muhlebach… - International Journal of …, 2023 - mdpi.com
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators, a new series of
therapeutics that correct and potentiate some classes of mutations of the CFTR, have …
therapeutics that correct and potentiate some classes of mutations of the CFTR, have …
Sonic hedgehog signaling is essential for pulmonary ionocyte specification in human and ferret Airway Epithelia
Pulmonary ionocytes express high levels of cystic fibrosis transmembrane conductance
regulator (CFTR), an anion channel that is critical for hydration of the airways and …
regulator (CFTR), an anion channel that is critical for hydration of the airways and …